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MettL7A Antibody

CAT: 0223-4889-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4889-01Size:0.02 mg
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Background
MettL7A Antibody: MettL7A belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.
NCBI Gene ID
25840
Swiss Prot
Q9H8H3
Accession Number
NP_054752
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
MettL7A Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1219 - MCF7 Cell Lysate
Concentration
1 mg/mL
Buffer
MettL7A Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MettL7A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of MettL7A are known to exist. This antibody is predicted to not cross-react with MettL7B.
Symbol
METTL7A
Positive Control 2
Cat. No. 17-012 - MCF7 Cell Slide
NCBI Official Name
Methyltransferase like 7A
NCBI Organism
Homo sapiens
Background Reference 01
Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70.
Background Reference 02
Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell1992; 69:915-26.
Background Reference 03
Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics1994; 3:1487-95.
Other Product Names
MettL7A Antibody: AAM-B, Methyltransferase-like protein 7A, Protein AAM-B
Tested Applications
ELISA, WB, ICC, IF
Protein ID
89145417
Physical Properties
Liquid

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