IL-17 Antibody

• Background:

  IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

• NCBI Gene ID:

  3605

• Swiss Prot:

  Q16552

• Accession Number:

  NP_002181

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Recombinant Protein Test (Figure 3) : Anit-IL-17 antibodies (4877) detected human IL-17 recombinant protein at different concentrations. Recombinant Protein Test4877

• Field of Research:

  Signal Transduction

• Purification:

  IL-17 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1208 - THP-1 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  IL-17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Isoform:

  Human IL-17 has only one isoform (155aa, 17.5kD) . Mouse IL-17 has one isoform (158aa, 17.5kD) and rat IL-17 also has one isoform (150aa, 16.9kD) . 4877 can detect only human isoform, but cannot detect mouse and rat.

• Symbol:

  IL17A

• Positive Control 2:

  Cat. No. 1288 - A20 Cell Lysate

• NCBI Official Name:

  Interleukin 17A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Miossec. Curr. Opin. Rheumatol.2000; 12:181-5.

• Background Reference 02:

  Paunovic et al. Rheumatol.2008; 47:771-6.

• Background Reference 03:

  Steinman. Nat. Med.2007; 13:139-145.

• Other Product Names:

  IL-17 Antibody: IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8

• Tested Applications:

  ELISA, WB

• Protein ID:

  4504651

• Physical Properties:

  Liquid