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Akirin2 Antibody

CAT: 0223-4803-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4803-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κ B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κ B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
NCBI Gene ID
55122
Swiss Prot
Q53H80
Accession Number
EAW48578
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
Akirin2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (100%)
Buffer
Akirin2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Akirin2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
AKIRIN2
NCBI Official Name
Akirin 2
NCBI Organism
Homo sapiens
Background Reference 01
Goto A, Matsushita K, Gesellchen V, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol.2008; 9:97-104.
Background Reference 02
Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol.2008; 9:7-9.
Background Reference 03
Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature2008; 451:254-5.
Background Reference 04
Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol.2005; 26:193-8.
Other Product Names
Akirin2 Antibody: FBI1, C6orf166, dJ486L4.2, Akirin-2
Tested Applications
ELISA, WB
Protein ID
119568963
Physical Properties
Liquid

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