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Akirin1 Antibody

CAT: 0223-4799-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4799-01Size:0.02 mg
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Background
Akirin1 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κ B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κ B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
NCBI Gene ID
79647
Swiss Prot
Q9H9L7
Accession Number
CAI16710
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
Akirin1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 - A549 Cell Lysate
Concentration
1 mg/mL
Buffer
Akirin1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Akirin1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
AKIRIN1
NCBI Official Name
Akirin 1
NCBI Organism
Homo sapiens
Background Reference 01
Goto A, Matsushita K, Gesellchen V, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol.2008; 9:97-104.
Background Reference 02
Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol.2008; 9:7-9.
Background Reference 03
Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature2008; 451:254-5.
Background Reference 04
Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol.2005; 26:193-8.
Other Product Names
Akirin1 Antibody: STRF2, C1orf108, Akirin-1
Tested Applications
ELISA, WB
Protein ID
55962136
Physical Properties
Liquid

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