Aldh3A2 Antibody

• Background:

  Aldh3A2 Antibody: Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD (P) (+) -dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.

• NCBI Gene ID:

  224

• Swiss Prot:

  P51648

• Accession Number:

  NP_001026976

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  Aldh3A2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1404 - Mouse Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat: (77%)

• Buffer:

  Aldh3A2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aldh3A2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least four isoforms of Aldh3A2 are known to exist. This antibody is predicted to have no cross-reactivity to Aldh3A1.

• Symbol:

  ALDH3A2

• NCBI Official Name:

  Aldehyde dehydrogenase 3 family, member A2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vasiliou V and Pappa A. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology2000; 61:192-8.

• Background Reference 02:

  Rizzo WB. Sjogren-Larsson syndrome: molecular genetics and biochemical pathogenesis of fatty aldehyde dehydrogenase deficiency. Mol. Genet. Metab.2007; 90:1-9.

• Other Product Names:

  Aldh3A2 Antibody: SLS, FALDH, ALDH10, Fatty aldehyde dehydrogenase, Aldehyde dehydrogenase 10

• Tested Applications:

  ELISA, WB

• Protein ID:

  73466520

• Physical Properties:

  Liquid