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NIPSNAP Antibody

CAT: 0223-4535-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4535-01Size:0.02 mg
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Background
NIPSNAP Antibody: NIPSNAP is a member of an evolutionarily well conserved gene family and has a strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. Recent studies have indicated that NIPSNAP is involved in the regulation of the Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6) . NIPSNAP1 associates with TRPV6 at the plasma membrane and inhibits TRPV6 currents. Other studies show that NIPSNAP's expression is reduced in the phenylketonuria (PKU) mouse brain, suggesting that NIPSNAP may play a role in memory.
NCBI Gene ID
8508
Swiss Prot
Q9BPW8
Accession Number
NP_003625
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
NIPSNAP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
NIPSNAP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NIPSNAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NIPSNAP1
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Nipsnap homolog 1 (C. elegans)
NCBI Organism
Homo sapiens
Background Reference 01
Seroussi E, Pan H-Q, Kedra D, et al. Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family. Gene1998; 212:13-20.
Background Reference 02
Schoeber JP, Topala CN, Lee KP, et al. Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity. Pflugers Arch.2008; epub.
Background Reference 03
Surendran S, Tyring SK and Matalon R. Expression of calpastatin, minopontin, NIPSNAP1, rabaptin-5 and neuronatin in the phenylketonuria (PKU) mouse brain: possible role on cognitive defect seen in PKU. Neurochem. Int.2005; 46:595-9.
Other Product Names
NIPSNAP Antibody: Protein NipSnap homolog 1, NipSnap1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
193211616
Physical Properties
Liquid

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