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Slitrk6 Antibody

CAT: 0223-4481-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4481-01Size:0.02 mg
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Background
Slitrk6 Antibody: SLIT and NTRK-like family 6 (Slitrk6) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Slitrk6 expression has been observed in tissues such as tongue, lung, gastrointestinal tract, and pancreas. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk6 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth. At least two isoforms of Slitrk6 are known to exisit.
NCBI Gene ID
84189
Swiss Prot
Q9H5Y7
Accession Number
Q9H5Y7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Slitrk6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1402 - Mouse Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
Slitrk6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Slitrk6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
Symbol
SLITRK6
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
SLIT and NTRK-like family, member 6
NCBI Organism
Homo sapiens
Background Reference 01
Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci.2003; 24:117-29.
Background Reference 02
Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene2003; 315:87-94.
Background Reference 03
Aruga J. Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Gene Expr. Patterns2003; 3:727-33.
Other Product Names
Slitrk6 Antibody: DFNMYP, SLIT and NTRK-like protein 6
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
59803110
Physical Properties
Liquid

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