FGF4 Antibody

• Background:

  FGF4 Antibody: Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.

• NCBI Gene ID:

  2249

• Swiss Prot:

  P08620

• Accession Number:

  P08620

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Cancer

• Purification:

  FGF4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1282 - 3T3 (NIH) Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (94%), Chicken: (88%)

• Buffer:

  FGF4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  FGF4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  FGF4

• Positive Control 2:

  Cat. No. 17-201 - 3T3/BALB Cell Slide

• NCBI Official Name:

  Fibroblast growth factor 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Powers CJ, McLeskey SW, and Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocr. Relat. Cancer2000; 7:165-97.

• Background Reference 02:

  Delli-Bovi P, Curatola AM, Kern FG, et al. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell1987; 50:729-37.

• Background Reference 03:

  Yoshida T, Ishimaru K, Sakamoto H, et al. Angiogenic activity of the recombinant hst-1 protein. Cancer Lett.1994; 83:261-268.

• Background Reference 04:

  Laufer E, Nelson CE, Johnson RL, et al. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell1994; 79:993-1003.

• Other Product Names:

  FGF4 Antibody: HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-4, HST, KS3, Fibroblast growth factor 4, Heparin secretory-transforming protein 1, FGF-4

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  122750

• Physical Properties:

  Liquid