FGF4 Antibody

CAT: 0223-4433-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4433-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
FGF4 Antibody: Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.
NCBI Gene ID
2249
Swiss Prot
P08620
Accession Number
P08620
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Cancer
Purification
FGF4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (94%), Chicken: (88%)
Buffer
FGF4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FGF4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
FGF4
Positive Control 2
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
Fibroblast growth factor 4
NCBI Organism
Homo sapiens
Background Reference 01
Powers CJ, McLeskey SW, and Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocr. Relat. Cancer2000; 7:165-97.
Background Reference 02
Delli-Bovi P, Curatola AM, Kern FG, et al. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell1987; 50:729-37.
Background Reference 03
Yoshida T, Ishimaru K, Sakamoto H, et al. Angiogenic activity of the recombinant hst-1 protein. Cancer Lett.1994; 83:261-268.
Background Reference 04
Laufer E, Nelson CE, Johnson RL, et al. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell1994; 79:993-1003.
Other Product Names
FGF4 Antibody: HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-4, HST, KS3, Fibroblast growth factor 4, Heparin secretory-transforming protein 1, FGF-4
Tested Applications
ELISA, WB, ICC, IF
Protein ID
122750
Physical Properties
Liquid

Related Products

CatalogName
4433PFGF4 Peptide
55-081FGF7 Antibody
42-903FGF5 Antibody
18-179FGF2 Antibody
79-709FGFR4 Antibody
23-095FGF6 Antibody
23-024FGFR4 Antibody
63-089FGFR4 Antibody
13-095FGF2 Antibody
13-246FGF1 Antibody

Alternative Products

CatalogName
MBS8590120-01FGF4 Antibody

Popular Products