TEM2 Antibody

CAT: 0223-4363-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4363-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
NCBI Gene ID
23551
Swiss Prot
Q96D21
Accession Number
Q96D21
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
TEM2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1472 - Rat Colon Tissue Lysate
Concentration
1 mg/mL
Buffer
TEM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TEM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
TEM2 antibody may cross-react with the closely related protein RASD1.
Symbol
RASD2
NCBI Official Name
RASD family, member 2
NCBI Organism
Homo sapiens
Background Reference 01
Vargiu P, Morte B, Manzano J, et al. Thyroid hormone regulation of rhes, a novel RAS homolog gene expressed in the striatum. Brain Res. Mol. Brain Res.2001; 94:1-8.
Background Reference 02
Spano D, Branchi I, Rosica A, et al. Rhes is involved in striatal function. Mol. Cell. Biol.2004; 24:5788-96.
Background Reference 03
Carson-Walter EB, Watkins DN, Nanda A, et al. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res.2001; 61:6649-55.
Background Reference 04
Yamamoto Y, Irie K, Nanda A, et al. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene2004; 23:3889-97.
Other Product Names
TEM2 Antibody: Rhes, TEM2, MGC:4834, GTP-binding protein Rhes, Ras homolog enriched in striatum
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
21362868
Physical Properties
Liquid

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