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CCDC98 Antibody

CAT: 0223-4321-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4321-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CCDC98 Antibody: CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
NCBI Gene ID
84142
Swiss Prot
Q6UWZ7
Accession Number
NP_620775
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
CCDC98 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1311 - Human Breast Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (93%), Chicken: (87%)
Buffer
CCDC98 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CCDC98 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
FAM175A
Positive Control 2
Cat. No. 10-001 - Human Breast Tissue Slide
NCBI Official Name
Family with sequence similarity 175, member A
NCBI Organism
Homo sapiens
Background Reference 01
Wang B, Matsuoka S, Balliff BA, et al. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science2007; 316:1194-1198.
Background Reference 02
Kim H, Huang J, and Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat. Struct. Mol. Biol.2007; 14:710-5.
Background Reference 03
Liu Z, Wu J, and Yu X. CCDC98 targets BRCA1 to DNA damage sites. Nat. Struct. Mol. Biol.2007; 14:716-20.
Other Product Names
CCDC98 Antibody: ABRA1, CCDC98, ABRA1, UNQ496/PRO1013, BRCA1-A complex subunit Abraxas, Coiled-coil domain-containing protein 98
Tested Applications
ELISA, WB, IHC-P
Protein ID
109148531
Physical Properties
Liquid

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