STEAP4 Antibody

• Background:

  STEAP4 Antibody: The six-transmembrane epithelial antigen of prostate 4 (STEAP4) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP3), STEAP4 promotes both iron and copper reduction. STEAP4 is highly expressed in placenta, lung, heart and prostate tissues, and overexpressed in prostate cancer cells compared to normal prostate cells. Overexpression of STEAP4 in prostate cells significantly increases cell growth and colony formation, suggesting STEAP4 may have a role in cell proliferation and prostate cancer progression.

• NCBI Gene ID:

  79689

• Swiss Prot:

  Q687X5

• Accession Number:

  EAW76907

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis, Cancer

• Purification:

  STEAP4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1464 - Rat Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  STEAP4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  STEAP4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least two isoforms are known to exist for this protein. This STEAP4 antibody does not cross-react with other STEAP proteins.

• Symbol:

  STEAP4

• NCBI Official Name:

  STEAP family member 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Korkmaz CG, Korkmaz KS, Kurys P, et al. Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer. Oncogene 2005; 24:4934-45.

• Background Reference 02:

  Ohgami RS, Campagna DR, McDonald A, et al. The Steap proteins are metalloreductases. Blood2006; 108:1388-94.

• Other Product Names:

  STEAP4 Antibody: TIARP, STAMP2, TNFAIP9, Metalloreductase STEAP4, Six-transmembrane epithelial antigen of prostate 4

• Tested Applications:

  ELISA, WB

• Protein ID:

  119597313

• Physical Properties:

  Liquid