STIM2 Antibody

CAT: 0223-4123-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4123-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
STIM2 Antibody: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER) -like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.
NCBI Gene ID
57620
Swiss Prot
Q9P246
Accession Number
NP_065911
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
STIM2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
STIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
STIM2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
STIM2
Positive Control 2
Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 3
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Stromal interaction molecule 2
NCBI Organism
Homo sapiens
Background Reference 01
2+
Background Reference 02
Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature2006; 441:179-85.
Background Reference 03
2+2+
Background Reference 04
Ca2+
Other Product Names
STIM2 Antibody: KIAA1482, Stromal interaction molecule 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
41349446
Physical Properties
Liquid

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