VISA Antibody

• Background :

  VISA Antibody: Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-κ B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKα , IKKβ and IKKε kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

• NCBI Gene ID :

  57506

• Swiss Prot :

  Q7Z434

• Accession Number :

  NP_065797

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Innate Immunity

• Purification :

  VISA Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1288 - A20 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  VISA Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  VISA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  MAVS

• Positive Control 2 :

  Cat. No. 1303 - Human Brain Tissue Lysate

• Positive Control 3 :

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name :

  Mitochondrial antiviral signaling protein

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Seth RB, Sun L, and Chen ZJ. Antiviral innate immunity pathways. Cell Res.2006; 16:141-7.

• Background Reference 02 :

  Xu LG, Wang YY, Han KJ, et al. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell2005; 19:727-40.

• Background Reference 03 :

  Meylan E, Curran J, Hofman K, et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature2005; 1167-72.

• Other Product Names :

  VISA Antibody: IPS1, VISA, IPS-1, CARDIF, IPS1, KIAA1271, Mitochondrial antiviral-signaling protein, CARD adapter inducing interferon beta, MAVS

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  83776598

• Physical Properties :

  Liquid