Products for Research Use Only
RegisterLogin

Bfl-1 Antibody

CAT: 0223-3873-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-3873-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Bfl-1 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells.
NCBI Gene ID
597
Swiss Prot
Q16548
Accession Number
NP_004040
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
Bfl-1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (92%)
Buffer
Bfl-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Bfl-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of Bfl-1 are known to exist; this antibody will only detect the larger isoform.
Symbol
BCL2A1
Positive Control 2
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Positive Control 3
Cat. No. 1302 - Human Lung Tissue Lysate
NCBI Official Name
BCL2-related protein A1
NCBI Organism
Homo sapiens
Background Reference 01
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
Background Reference 02
Choi SS, Park IC, Yun JW, et al. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene 1995; 11:1693-8.
Background Reference 03
Kim JK, Kim KD, Lee E, et al. Up-regulation of Bfl-1/A1 via NF-κ B activation in cisplatin-resistant human bladder cancer cell line. Cancer Lett. 2004; 212:61-70.
Background Reference 04
Zhang H, Cowan-Jacob SW, Simonen M, et al. Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. J. Biol. Chem. 2000; 275:11092-9.
Other Product Names
Bfl-1 Antibody: GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5, GRS, Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4757840
Physical Properties
Liquid

Related Products

CatalogName
3875PBfl-1 Peptide
3873PBfl-1 Peptide
36-149BAFF Antibody [1-35-1]
33-439CD99 Antibody [HO36-1.1]
33-215TTF-1 Antibody [8G7G3/1]
34-055TIA-1 Antibody [TRIA1-1]
33-951Arginase 1 Antibody [T1ARG-1]
33-860PD-1 Antibody [PD203-1]
33-881MUC-1 Antibody [MCN01-1]
79-773Oct-1 Antibody

Alternative Products

CatalogName
MBS9405800-01Bfl-1 Antibody
APR06415GPolyclonal Bfl-1 Antibody
E90134A1/Bfl-1 Antibody
24436Bfl Antibody
C21611-100uLA1/Bfl-1 Antibody [N2F22]
A03850-1Anti-Bfl-1 BCL2A1 Antibody
C19506-50uLA1/Bfl-1 Antibody [D21F14]
CST 64310SA1/Bfl-1 (E4P2I) Rabbit Monoclonal Antibody
CST 14093TA1/Bfl-1 (D1A1C) Rabbit Monoclonal Antibody
CST 24951TA1/Bfl-1 (E3U2F) Rabbit Monoclonal Antibody

Popular Products