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TIM-1 Antibody

CAT: 0223-3811-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3811-01Size:0.02 mg
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Background
TIM-1 Antibody: The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
NCBI Gene ID
26762
Swiss Prot
Q96D42
Accession Number
NP_036338
Host
Rabbit
Reactivity
Human
Immunogen
3811
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar TIM-1 expression profile in human cell lines detected by two independent anti-TIM-1 antibodies that recognize different epitopes, 3809 against N-terminus domain and 3811 against the central domain. TIM-1 proteins are detected in all the tested cell lines except MCF-7 at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3809 3811 siRNA knockdown validation (Figure 3) : Anti-TIM-1 antibody (3811) specificity was further verified by TIM-1 specific siRNA knockdown. TIM-1 signal in HeLa cells transfected with TIM-1 siRNAs was much weaker in comparison with that in HeLa cells transfected with control siRNAs. siRNA knockdown validation3811
Field of Research
Immunology, Neuroscience, Signal Transduction, Growth Factors
Purification
TIM-1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (50%), Rat: (43.7%)
Buffer
TIM-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TIM-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human TIM-1 has 5 isoforms, including isoform a precursor (364aa, 39kD), isoform a (364aa, 39kD), isoform b precursor (401aa, 44kD), isoform b (359aa, 39kD), and isoform c (359aa, 39kD) . This antibody detects human isoform b precursor. Mouse TIM-1 has 3 isoforms, including isoform a precursor (305aa, 33kD), isoform b precursor (282aa, 31kD) and isoform b (282aa, 31kD) . Rat TIM-1 has only one isoform identified so far (307aa, 34kD) .
Symbol
HAVCR1
Positive Control 2
Cat. No. 1203 - A549 Cell Lysate
Positive Control 3
Cat. No. 1224 - Daudi Cell Lysate
Positive Control 4
Cat. No. 1210 - 293 Cell Lysate
NCBI Official Name
Hepatitis A virus cellular receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Feigelstock et al. J. Virol. 1998; 72:6621-8
Background Reference 02
Ichimura et al. J. Biol. Chem. 1998; 273:4135-42
Background Reference 03
Meyers et al. Mol. Med. 2005; 11:362-9
Background Reference 04
Mayers et al. Nat. Immunol. 2005;6:455-64.
Other Product Names
TIM-1 Antibody: TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1
Tested Applications
ELISA, WB
Protein ID
153085427
Physical Properties
Liquid

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