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TIM-1 Antibody

CAT: 0223-3809-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3809-01Size:0.02 mg
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Background
TIM-1 Antibody: The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
NCBI Gene ID
26762
Swiss Prot
Q96D42
Accession Number
NP_036338
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
3809
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar TIM-1 expression profile in human cell lines detected by two independent anti-TIM-1 antibodies that recognize different epitopes, 3809 against N-terminus domain and 3811 against the central domain. TIM-1 proteins are detected in all the tested cell lines except MCF-7 at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3809 3811 siRNA knockdown validation (Figure 3) : Anti-TIM-1 antibody (3809) specificity was further verified by TIM-1 specific siRNA knockdown. TIM-1 signal in HeLa cells transfected with TIM-1 siRNAs was much weaker in comparison with that in HeLa cells transfected with control siRNAs. siRNA knockdown validation3809
Field of Research
Immunology, Neuroscience, Signal Transduction, Growth Factors
Purification
TIM-1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (56.3%)
Buffer
TIM-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TIM-1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human TIM-1 has 5 isoforms, including isoform a precursor (364aa, 39kD), isoform a (364aa, 39kD), isoform b precursor (401aa, 44kD), isoform b (359aa, 39kD), and isoform c (359aa, 39kD) . This antibody detects human isoform b precursor. Mouse TIM-1 has 3 isoforms, including isoform a precursor (305aa, 33kD), isoform b precursor (282aa, 31kD) and isoform b (282aa, 31kD) . Rat TIM-1 has only one isoform identified so far (307aa, 34kD) .
Symbol
HAVCR1
Positive Control 2
Cat. No. 1203 - A549 Cell Lysate
Positive Control 3
Cat. No. 1224 - Daudi Cell Lysate
Positive Control 4
Cat. No. 11-401 - Human Uterus Tissue Slide
NCBI Official Name
Hepatitis A virus cellular receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Feigelstock et al. J. Virol. 1998; 72:6621-8
Background Reference 02
Ichimura et al. J. Biol. Chem. 1998; 273:4135-42
Background Reference 03
Meyers et al. Mol. Med. 2005; 11:362-9
Background Reference 04
Mayers et al. Nat. Immunol. 2005;6:455-64.
Other Product Names
TIM-1 Antibody: TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
153085427
Physical Properties
Liquid

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