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IL-23 Antibody

CAT: 0223-3795-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3795-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
NCBI Gene ID
51561
Swiss Prot
Q9NPF7
Accession Number
AAH66268
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
3795
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 2) : Anti-IL-23 antibodies (3795) detected human IL-23 recombinant protein at different concentrations. Recombinant Protein Test3795 Induced Expression Validation (Figure 6) : IL-23 expression detected by anit-AIF antibodies was up-regulated by tape stripping. Induced Expression Validation
Field of Research
Immunology, Chemokines & Cytokines, Neuroscience
Purification
IL-23 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1414 - Mouse Pancreas Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Horse: (94%), Pig: (82%), Rat: (76%), Guinea pig: (76%)
Buffer
IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-23 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human IL-23 has one isoform (189aa, 20.7kD) . Mouse IL-23 has one isoform (196aa, 22.1kD) and Rat IL-23 also has one isoform (196aa, 22kD) . 3795 can detect human and mouse, and possibly detect rat.
Symbol
IL23A
NCBI Official Name
Interleukin 23, alpha subunit p19
NCBI Organism
Homo sapiens
Background Reference 01
Hunter. Nat. Rev. Immunol. 2005; 5:521-31.
Background Reference 02
Oppmann et al. Immunity 2000; 13:715-25.
Background Reference 03
Sheibanie et al. FASEB J. 2004; 18:1318-20.
Background Reference 04
Pirhonen et al. J. Immunol. 2002; 169:5673-8.
Citation 01
27551155
Other Product Names
IL-23 Antibody: P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
42542809
Physical Properties
Liquid

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