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SOCS1 Antibody

CAT: 0223-3767-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3767-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SOCS1 Antibody: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
NCBI Gene ID
8651
Swiss Prot
O15524
Accession Number
CAB92528
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Chemokines & Cytokines, Cancer
Purification
SOCS1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
SOCS1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SOCS1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SOCS1
NCBI Official Name
Suppressor of cytokine signaling 1
NCBI Organism
Homo sapiens
Background Reference 01
Rakesh K and Agrawal DK. Controlling cytokine signaling by constitutive inhibitors. Biochem. Pharm. 2005; 70:649-57.
Background Reference 03
Kile BT, Schulman BA, Alexander WS, et al. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 2002; 27:235-41.
Background Reference 04
Mansell A, Smith R, Doyle SL, et al. Suppressor of cytokine signaling 1 negatively mediates Toll-like receptor signaling by mediating Mal degradation. Nat. Immunol. 2006; 7:148-55.
Other Product Names
SOCS1 Antibody: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein
Tested Applications
ELISA, WB
Protein ID
8217331
Physical Properties
Liquid

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