DDX3 Antibody

• Background :

  DDX3 Antibody: DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases. DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome. DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation. It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.

• NCBI Gene ID :

  1654

• Swiss Prot :

  O00571

• Accession Number :

  AAC34298

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Infectious Disease

• Purification :

  DDX3 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  DDX3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  DDX3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  DDX3 antibody will detect both DDX3 and DBY.

• Symbol :

  DDX3X

• Positive Control 2 :

  Cat. No. 17-011 - Hep G2 Cell Slide

• NCBI Official Name :

  DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Linder P, Lasko PF, Ashburner M, et al. Birth of the D-E-A-D box. Nature 1989; 337:121-2.

• Background Reference 02 :

  Park SH, Lee SG, Kim Y, et al. Assignment of a human putative RNA helicase gene, DDX3, to human X chromosome bands p11.3-->p11.23. Cytogenet. Cell Genet. 1998; 81:178-9.

• Background Reference 03 :

  Lahn BT and Page DC. Functional coherence of the human Y chromosome. Science 1997; 278:675-80.

• Background Reference 04 :

  Abdelhaleem M. RNA helicases: regulators of differentiation. Clin. Biochem. 2005; 38:499-503.

• Other Product Names :

  DDX3 Antibody: DBX, DDX3, HLP2, DDX14, DBX, ATP-dependent RNA helicase DDX3X, DEAD box protein 3, X-chromosomal

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  3523150

• Physical Properties :

  Liquid