TLR5 Antibody

• Background:

  TLR5 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-κ B, leading to the activation of TNF-α and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires'disease and demonstrates the importance of TLR5 in the innate immune response.

• NCBI Gene ID:

  7100

• Swiss Prot:

  O60602

• Accession Number:

  NP_003259

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  TLR5 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1218 – HT29 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TLR5 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TLR5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TLR5

• Positive Control 2:

  Cat. No. 17-008 - THP-1 Cell Slide

• NCBI Official Name:

  Toll-like receptor 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol.2003; 21:335-76.

• Background Reference 02:

  Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol.2002; 20:197-216.

• Background Reference 03:

  McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm.2004; 41:577-82.

• Background Reference 04:

  Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature2001; 410:1099-103.

• Other Product Names:

  TLR5 Antibody: TIL3, SLEB1, MELIOS, TIL3, Toll-like receptor 5

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  16751843

• Physical Properties:

  Liquid