Products for Research Use Only
RegisterLogin

LAMP-1 Antibody

CAT: 0223-3629-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-3629-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
LAMP-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin) . A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, suggesting that each protein possesses some unique and necessary functions.
NCBI Gene ID
3916
Swiss Prot
P11279
Accession Number
NP_005552
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Autophagy
Purification
LAMP-1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
LAMP-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LAMP-1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
LAMP-1 antibody is predicted to not cross-react with LAMP-2. Due to extensive post-translational modification, LAMP-1 often migrates at higher than predicted molecular weight in SDS-PAGE.
Symbol
LAMP1
Positive Control 2
Cat. No. 1320 - Human Colon Tissue Lysate
NCBI Official Name
Lysosomal-associated membrane protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004; 23:2891-906.
Background Reference 02
Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis1993; 14:2501-5.
Background Reference 03
Kamada Y, Funakoshi T, Shintani T, et al. Tor-mediated induction of autophagy via Apg1 protein kinase complex. J. Cell. Biol. 2000; 150:1507-13.
Background Reference 04
Chen JW, Murphy TL, Willingham MC, et al. Identification of two lysosomal membrane glycoproteins. J. Cell Biol. 1985; 101:85-95.
Other Product Names
LAMP-1 Antibody: LAMPA, CD107a, LGP120, Lysosome-associated membrane glycoprotein 1, CD107 antigen-like family member A, LAMP-1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
112380628
Physical Properties
Liquid

Related Products

CatalogName
3629PLAMP-1 Peptide
3627-01mgLAMP-2 Antibody
3627-002mgLAMP-2 Antibody
3627-01LAMP-2 Antibody
91-862LAMP Recombinant Protein
3627PLAMP-2 Peptide
33-510LAMP3 Antibody [LAMP3/529]
18-856LAMP3 Antibody
25-709LAMP3 Antibody
59-748LAMP2 Antibody

Alternative Products

CatalogName
MBS9411912-01LAMP-1 Antibody
5077-100LAMP-1 Antibody (Center)
A00780Anti-LAMP-1 Antibody
APR08117GPolyclonal LAMP-1 Antibody
24358LAMP Antibody
OASB00744-500UGMouse CD107a/LAMP-1 Antibody
GTR18229532LAMP-1 Antibody FITC Conjugated
abx229292-01CD107a/LAMP-1 Antibody (PE)
abx229293-01CD107a/LAMP-1 Antibody (APC)
OASB01162-100UGHuman CD107a/LAMP-1 Antibody

Popular Products