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SARS-CoV Matrix Antibody

CAT: 0223-3527-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3527-01Size:0.02 mg
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Background
Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3) . It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4) .
NCBI Gene ID
1489672
Swiss Prot
P59596
Accession Number
P59596
Host
Rabbit
Reactivity
Virus
Immunogen
3527
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease, COVID-19
Purification
SARS-CoV Matrix Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Homology
Predicted reactivity based on immunogen sequence: SARS-CoV-2 Matrix protein: (identity 77%, homology 93%)
Buffer
SARS-CoV Matrix Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SARS-CoV Matrix antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Applications Notes
SARS-CoV Matrix antibody can be used for the detection of SARS-CoV Matrix protein in ELISA. It will detect 5 ng of free peptide at 1 μ g/mL.
Isoform
SARS-CoV Matrix has one isoform (222aa) .
Symbol
M
NCBI Official Name
Membrane protein
NCBI Organism
SARS coronavirus
Background Reference 01
Gorbalenya. bioRxiv: 2020.
Background Reference 02
Hui et al. Int J Infect Dis. 2020;91:264-266.
Background Reference 03
Neuman, et al. J Struct Biol. 2011;174 (1) :11–22.
Background Reference 04
Liu et al. J Infect Dis. 2010;202 (8) :1171-80.
Citation 01
21775467
Citation 02
32743576
Other Product Names
SARS-CoV Matrix Antibody: Membrane protein, E1 glycoprotein, M protein
Tested Applications
ELISA
Protein ID
30173398
Physical Properties
Liquid

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