SARS-CoV Spike Antibody

• Background:

  SARS-CoV Spike antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome) . Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

• NCBI Gene ID:

  1489668

• Swiss Prot:

  P59594

• Accession Number:

  P59594

• Host:

  Rabbit

• Reactivity:

  Virus

• Immunogen:

  3225

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  SARS-CoV Spike antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Homology:

  Predicted reactivity based on immunogen sequence: SARS-CoV2 Spike protein: (identity 40%, homology 56%)

• Buffer:

  SARS-CoV Spike antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SARS-CoV Spike antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Applications Notes:

  SARS-CoV Spike antibody can be used for the detection of SARS-CoV Spike protein in ELISA. It will detect 5 ng of free peptide at 1 μ g/mL.

• Isoform:

  SARS-CoV Spike has one isoform (1255aa) .

• Symbol:

  S

• NCBI Official Name:

  Spike glycoprotein

• NCBI Organism:

  SARS coronavirus

• Background Reference 01:

  Marra et al. Science 2003;300:1399-404.

• Background Reference 02:

  Rota et al. Science 2003;300:1394-9.

• Background Reference 03:

  Navas-Nartin et al. J Neurovirol. 2004;10:75-85.

• Background Reference 04:

  Li et al. Nature 2003;426:450-4.

• Other Product Names:

  SARS-CoV Spike antibody: E2, Spike glycoprotein, E2, S glycoprotein

• Tested Applications:

  ELISA

• Protein ID:

  30173397

• Physical Properties:

  Liquid