Caspase-7 Antibody

• Background:

  Caspase-7 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.

• NCBI Gene ID:

  840

• Swiss Prot:

  P55210

• Accession Number:

  P55210

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Neuroscience, Cancer

• Purification:

  Caspase-7 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  Caspase-7 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Caspase-7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  Depending on cell lines or tissues used, other cleavage products may be observed.

• Symbol:

  CASP7

• NCBI Official Name:

  Caspase 7, apoptosis-related cysteine peptidase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

• Background Reference 02:

  Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.

• Background Reference 03:

  Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.

• Background Reference 04:

  Juan TSC, McNiece IK, Argento JM, et al. Identification and mapping of Casp7, a cysteine protease resembling CPP32b, Interleukin-1b converting enzyme, and CED-3. Genomics 1997; 40:86-93.

• Other Product Names:

  Caspase-7 Antibody: MCH3, CMH-1, LICE2, CASP-7, ICE-LAP3, MCH3, Caspase-7, Apoptotic protease Mch-3

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  1730092

• Physical Properties:

  Liquid