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Anthrax Protective Antigen Antibody

CAT: 0223-3413-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3413-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Anthrax Protective Antigen Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF) . PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8) /anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
NCBI Gene ID
3361714
Swiss Prot
P13423
Accession Number
AAF86457
Host
Rabbit
Reactivity
Bacteria
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
Anthrax Protective Antigen Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Buffer
Anthrax Protective Antigen Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Anthrax Protective Antigen antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Applications Notes
Anthrax protective antigen antibody can be used for the detection of Anthrax protective antigen protein in ELISA. It will detect 10 ng of free peptide at 1 μ g/mL.
Symbol
Pxo1_110
NCBI Official Name
Protective antigen
NCBI Organism
Bacillus anthracis
Background Reference 01
Schwartz MN. Recognition and management of anthrax - an update. New Engl. J. Med. 2001; 345:1621-6.
Background Reference 02
Moayeri M and Leppla SH. The roles of anthrax toxin in pathogenesis. Curr. Opin. Microbiol. 2004; 7:19-24.
Background Reference 03
Bradley KA, Mogridge J, Mourez M, et al. Identification of the cellular receptor for anthrax toxin. Nature 2001; 414:225-9.
Background Reference 04
Scobie HM, Rainey GJ, Bradley KA, et al. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc. Natl. Acad. Sci. USA 2003; 100:5170-4.
Other Product Names
Anthrax Protective Antigen Antibody: pag, pXO1-110, BXA0164, GBAA_pXO1_0164, Protective antigen, Anthrax toxins translocating protein, PA
Tested Applications
ELISA
Protein ID
9280533
Physical Properties
Liquid

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