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ACE2 Antibody

CAT: 0223-3215-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3215-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans
NCBI Gene ID
59272
Swiss Prot
Q9BYF1
Accession Number
NP_068576
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
3215
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar ACE2 expression profile in human cell lines detected by three independent anti-ACE2 antibodies that recognize different epitopes, 3215 against central domain, 3217 against C-terminus domain and 3227 against N-terminus domain. ACE2 proteins are detected in the most tested tissues at different expression levels by three independent antibodies. Independent Antibody Validation in Cell lines3215 32173227
Field of Research
Infectious Disease
Purification
ACE2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Buffer
ACE2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ACE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Anti-ACE2 has no cross response to ACE1.
Isoform
Human ACE2 has 2 isoforms, including isoform 1 (805aa, 93kD) and isoform 2 (555aa, 64kD) . Mouse ACE2 also has 2 isoforms, including isoform 1 (805aa, 92kD) and isoform 2 (353aa, 40kD) . Rat ACE2 has one isoform (805aa, 93kD) . 3215 can detect human, mouse and rat.
Symbol
ACE2
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
Positive Control 3
Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 4
Cat. No. 1313 - Human Testis Tissue Lysate
NCBI Official Name
Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
NCBI Organism
Homo sapiens
Background Reference 01
Donoghue et al. Circ. Res. 2000;87:1-9.
Background Reference 02
Tipnis et al. J Biol. Chem. 2000;275:33238-43.
Background Reference 03
Li et al. Nature 2003;426:450-4.
Background Reference 04
Lu et al. The Lancet 2020 (published online) .
Background Reference 05
Crackower et al. Nature 2002;417:822-8.
Other Product Names
ACE2 Antibody: ACEH, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACEH, SARS-CoV receptor, SARS-CoV-2 receptor
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
11225609
Physical Properties
Liquid

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