ACE2 Antibody

• Background:

  COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans

• NCBI Gene ID:

  59272

• Swiss Prot:

  Q9BYF1

• Accession Number:

  NP_068576

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  3215

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Independent Antibody Validation in Cell lines (Figure 1) shows similar ACE2 expression profile in human cell lines detected by three independent anti-ACE2 antibodies that recognize different epitopes, 3215 against central domain, 3217 against C-terminus domain and 3227 against N-terminus domain. ACE2 proteins are detected in the most tested tissues at different expression levels by three independent antibodies. Independent Antibody Validation in Cell lines3215 32173227

• Field of Research:

  Infectious Disease

• Purification:

  ACE2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1305 - Human Kidney Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (94%)

• Buffer:

  ACE2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ACE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  Anti-ACE2 has no cross response to ACE1.

• Isoform:

  Human ACE2 has 2 isoforms, including isoform 1 (805aa, 93kD) and isoform 2 (555aa, 64kD) . Mouse ACE2 also has 2 isoforms, including isoform 1 (805aa, 92kD) and isoform 2 (353aa, 40kD) . Rat ACE2 has one isoform (805aa, 93kD) . 3215 can detect human, mouse and rat.

• Symbol:

  ACE2

• Positive Control 2:

  Cat. No. 10-401 - Human Kidney Tissue Slide

• Positive Control 3:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Positive Control 4:

  Cat. No. 1313 - Human Testis Tissue Lysate

• NCBI Official Name:

  Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Donoghue et al. Circ. Res. 2000;87:1-9.

• Background Reference 02:

  Tipnis et al. J Biol. Chem. 2000;275:33238-43.

• Background Reference 03:

  Li et al. Nature 2003;426:450-4.

• Background Reference 04:

  Lu et al. The Lancet 2020 (published online) .

• Background Reference 05:

  Crackower et al. Nature 2002;417:822-8.

• Other Product Names:

  ACE2 Antibody: ACEH, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACEH, SARS-CoV receptor, SARS-CoV-2 receptor

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  11225609

• Physical Properties:

  Liquid