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IL-21 Antibody

CAT: 0223-2465-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2465-01Size:0.02 mg
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Background
IL-21 Antibody: A novel cytokine was recently identified in human and mouse and designated IL-21, which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
NCBI Gene ID
59067
Swiss Prot
Q9HBE4
Accession Number
NP_068575
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
2465
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell Lines (Figure 2) shows similar IL-21 expression profile in human and mouse cell lines detected by two independent anti-IL-21 antibodies that recognize different epitopes, 2465 against central domain and 2463 against C-terminus domain. IL-21 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell Lines2465 2463 Recombinant Protein Test (Figure 4) : Anit-IL-21 antibodies (2465) detected human IL-21 recombinant protein. Recombinant Protein Test2465 Regulated expression validation (Figure 6, 7, 8) : IL-21 expression detected by anit-IL-21 antibodies (2465) was up down-regulated by WRT treatment (figure 7) or was up-regulated in Hp positive patients (figure 8) and in patients with Crohn’s disease (figure 6) . Regulated expression validation2465
Field of Research
Chemokines & Cytokines, Cancer
Purification
IL-21 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1209 - HL60 Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (87%)
Buffer
IL-21 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-21 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of IL-21 are known to exist; this antibody will detect both isoforms. IL-21 antibody is predicted to not cross-react with other members of the interleukin protein family.
Isoform
Human IL-21 has 2 isoforms, including isoform 1 (162aa, 18.7kD) and isoform 2 (153aa, 17.6kD) . Mouse IL-21 has one isoform (146aa, 16.8kD) and Rat IL-21 also has one isoform (146aa, 17.1kD) . 2465 can detect both human isoforms and also detect mouse and rat.
Symbol
IL21
Positive Control 2
Cat. No. 17-004 - K-562 Cell Slide
NCBI Official Name
Interleukin 21
NCBI Organism
Homo sapiens
Background Reference 01
Parrish-Novak et al. Nature 2000; 408:57-63.
Background Reference 02
Ozaki et al. Proc. Natl. Acad. Sci. USA. 2000; 97:11439-44.
Background Reference 03
Asao et al. J. Immunol. 2001; 167:1-5.
Citation 01
15765404
Citation 02
22785229
Citation 03
17442980
Other Product Names
IL-21 Antibody: Za11, IL-21, Interleukin-21, Za11
Tested Applications
ELISA, WB, ICC
Protein ID
11141875
Physical Properties
Liquid

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