IL-21 Receptor Antibody

• Background:

  IL-21 Receptor Antibody: A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. Both IL-21R and the gammac are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

• NCBI Gene ID:

  50615

• Swiss Prot:

  Q9HBE5

• Accession Number:

  NP_068570

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Chemokines & Cytokines

• Purification:

  IL-21 Receptor Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1207 - Raji Cell Lysate

• Concentration:

  1 mg/ml

• Buffer:

  IL-21 Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  IL-21 Receptor antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  IL21R

• Positive Control 2:

  Cat. No. 1462 - Rat Lung Tissue Lysate

• NCBI Official Name:

  Interleukin 21 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408 (6808) :57-63.

• Background Reference 02:

  Ozaki K, Kikly K, Michalovich D, et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci USA. 2000;97 (21) :11439-44.

• Background Reference 03:

  Asao H, Okuyama C, Kumaki S, et al. the common γ -chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167 (1) :1-5.

• Background Reference 04:

  Vosshenrich CA, Di Santo JP. Cytokines: IL-21 joins the γ (c) -dependent network.Curr Biol. 2001;11 (5) :R175-7.

• Other Product Names:

  IL-21 Receptor Antibody: NILR, CD360, NILR, UNQ3121/PRO10273, Interleukin-21 receptor, Novel interleukin receptor, IL-21 receptor

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  11141869

• Physical Properties:

  Liquid