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PERP Antibody

CAT: 0223-2451-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2451-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PERP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
NCBI Gene ID
64058
Swiss Prot
Q9JK95
Accession Number
NP_071404
Host
Rabbit
Reactivity
Human
Immunogen
2451
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar PERP expression profile in human cell lines detected by two independent anti-PERP antibodies that recognize different epitopes, 2451 against C-terminus domain and 57-777 against C-terminus domain. PERP proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines2451 57-777
Field of Research
Apoptosis
Purification
PERP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat (100%) ; Mouse (82%)
Buffer
PERP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PERP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human PERP has one isoform (193aa, 21kD) . Mouse PERP has one isoform (193aa, 21.6kD) and Rat PERP also has one isoform (193aa, 21.6kD) . 2451 can detect human, mouse and rat.
Symbol
Perp
Positive Control 2
Cat. No. 17-002 - A-431 Cell Slide
NCBI Official Name
PERP, TP53 apoptosis effector
NCBI Organism
Mus musculus
Background Reference 01
Matsuoka et al. Science 1998; 282:1893-7.
Background Reference 02
Tanaka et al. Nature 2000; 404:42-9.
Background Reference 03
Oda et al. Science 2000; 288:1053-8.
Background Reference 04
Oda et al. Cell 2000; 102:849-62.
Other Product Names
PERP Antibody: THW, KCP1, PIGPC1, KRTCAP1, 1110017A08Rik, Krtcap1, p53 apoptosis effector related to PMP-22, Keratinocyte-associated protein 1, KCP-1
Tested Applications
ELISA, WB, ICC
Protein ID
11528520
Physical Properties
Liquid

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