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Caspase-12 Antibody

CAT: 0223-2327-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2327-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis) . The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP) . Caspase-12 mediates cytotoxicity induced by amyloid-beta.
NCBI Gene ID
12364
Swiss Prot
O08736
Accession Number
CAA73532
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
Caspase-12 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Caspase-12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
Casp12
Positive Control 2
Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 3
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Positive Control 4
Cat. No. 1404 - Mouse Liver Tissue Lysate
NCBI Official Name
Caspase 12
NCBI Organism
Mus musculus
Background Reference 01
Nakagawa T, Zhu Human, Mouseorishima N, el al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β . Nature 2000; 403:98-103.
Background Reference 02
Mehmet H. Caspases find a new place to hide. Nature 2000; 403:29-30
Background Reference 03
Van de Craen M, Vandenabeele P, Declercq W, et al. Characterization of seven murine caspase family members. FEBS Lett 1997; 403:61-9.
Other Product Names
Caspase-12 Antibody: Caspase-12, CASP-12
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
2094806
Physical Properties
Liquid

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