BACE2 Antibody

• Background:

  BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) . BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

• NCBI Gene ID:

  25825

• Swiss Prot:

  Q9Y5Z0

• Accession Number:

  AAF17078

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  BACE2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1301 - Human Heart Tissue Lysate

• Concentration:

  1 mg/ml

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)

• Buffer:

  BACE2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  BACE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  BACE2

• Positive Control 2:

  Cat. No. 1461 - Rat Heart Tissue Lysate

• NCBI Official Name:

  Beta-site APP-cleaving enzyme 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vassar R, et al. β -secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999;286:735-41

• Background Reference 02:

  Hussain I, et al. Identification of a novel aspartic protease (Asp 2) as β -secretase. Mol Cell Neurosci 1999;14:419-27

• Background Reference 03:

  Sinha S, et al. Purification and cloning of amyloid precursor protein β -secretase from human brain. Nature 1999;402:537-40

• Background Reference 04:

  Yan R, et al. Membrane-anchored aspartyl protease with Alzheimer's disease β -secretase activity. Nature 1999;402:533-7

• Other Product Names:

  BACE2 Antibody: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, UNQ418/PRO852, Beta-secretase 2, Aspartic-like protease 56 kDa, ASP1

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  6561812

• Physical Properties:

  Liquid