BACE2 Antibody

CAT: 0223-2247-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-2247-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) . A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
NCBI Gene ID
25825
Swiss Prot
Q9Y5Z0
Accession Number
AAF17078
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
BACE2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1301 - Human Heart Tissue Lysate
Concentration
1 mg/mL
Buffer
BACE2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BACE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
BACE2
Positive Control 2
Cat. No. 1401 - Mouse Heart Tissue Lysate
NCBI Official Name
Beta-site APP-cleaving enzyme 2
NCBI Organism
Homo sapiens
Background Reference 01
Vassar R, et al. β -secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286:735-41.
Background Reference 02
Hussain I, et al. Identification of a novel aspartic protease (Asp 2) as β -secretase. Mol Cell Neurosci 1999; 14:419-27.
Background Reference 03
Sinha S, et al. Purification and cloning of amyloid precursor protein β -secretase from human brain. Nature 1999; 402:537-40.
Background Reference 04
Yan R, et al. Membrane-anchored aspartyl protease with Alzheimer's disease β -secretase activity. Nature 1999; 402:533-7.
Other Product Names
BACE2 Antibody: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, UNQ418/PRO852, Beta-secretase 2, Aspartic-like protease 56 kDa, ASP1
Tested Applications
ELISA, WB, IHC-P
Protein ID
6561812
Physical Properties
Liquid

Related Products

CatalogName
2249PBACE2 Peptide
2247PBACE2 Peptide
57-886BACH2 Antibody
48-373BACE1 Antibody
25-527BACH2 Antibody
2253-002mgBACE Antibody
2253-01mgBACE Antibody
2253-01BACE Antibody
32-238BACE1 Antibody [3C1C3]
2253PBACE Peptide

Alternative Products

CatalogName
MBS8605104-01BACE2 Antibody

Popular Products