BAFF Antibody

CAT: 0223-2221-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-2221-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BAFF Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κ B and c-jun N-terminal Kinase) . BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.
NCBI Gene ID
10673
Swiss Prot
Q9Y275
Accession Number
NP_006564
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
2221
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 3) : Anti-BAFF antibodies (2221) detected human BAFF recombinant protein at different concentrations. Recombinant Protein Test2221 Regulated expression validation (Figure 6-8) : BAFF expression detected by anit-BAFF antibodies (2221) was up-regulated in patients with myloma or Graves’ disease or in murine transplanted heart. Regulated expression validation2221
Field of Research
Chemokines & Cytokines, Cancer
Purification
BAFF Antibody is Ion exchange chromatography purified.
Positive Control
Cat. No. 1209 - HL60 Cell Lysate
Concentration
1 mg/mL
Buffer
BAFF Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BAFF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human BAFF has 3 isoforms, including isoform 1 (285aa, 31kD), isoform 2 (266aa, 29kD) and isoform 3 (164aa, 17.6kD) . Mouse BAFF has 2 isoforms, including isoform 1 (309aa, 34kD) and isoform 2 (290aa, 32kD) . Rat BAFF has only one isoform (274aa, 30kD) . 2221 can detect two longer human isoforms, mouse and rat.
Symbol
TNFSF13B
Positive Control 2
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Positive Control 3
Cat. No. 17-009 - HL-60 Cell Slide
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 13b
NCBI Organism
Homo sapiens
Background Reference 01
Moore et al. Science 1999;285:260-3.
Background Reference 02
Schneider et al. J Exp Med 1999;189:1747-56.
Background Reference 03
Shu et al. J Leukoc Biol 1999;65:680-3.
Background Reference 04
Mukhopadhyay et al. J Biol Chem 1999 ;274:15978-81.
Citation 01
16818641
Citation 02
26214745
Citation 03
15368291
Citation 04
12867412
Other Product Names
BAFF Antibody: DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, UNQ401/PRO738, Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator
Tested Applications
ELISA, WB, ICC, IF, IHC
Protein ID
5730097
Physical Properties
Liquid

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