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BAFF Receptor Antibody

CAT: 0223-3097-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3097-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BAFF Receptor Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-κ B and c-jun N-terminal kinase.
NCBI Gene ID
115650
Swiss Prot
Q96RJ3
Accession Number
AAK91826
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Chemokines & Cytokines
Purification
BAFF Receptor Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
BAFF Receptor Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BAFF Receptor antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
20 kDa
Fragment
IgG
Symbol
TNFRSF13C
Positive Control 2
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Positive Control 3
Cat. No. 1466 - Rat Spleen Tissue Lysate
Positive Control 4
Cat. No. 1315 - Human Tonsil Tissue Lysate
Positive Control 5
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 13C
NCBI Organism
Homo sapiens
Background Reference 01
Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3
Background Reference 02
Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56
Background Reference 03
Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3
Background Reference 04
Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κ B, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81
Other Product Names
BAFF Receptor Antibody: BAFFR, CD268, CVID4, BAFF-R, BROMIX, prolixin, BAFFR, BR3, Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
15208475
Physical Properties
Liquid

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