BAFF Receptor Antibody

• Background:

  BAFF Receptor Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-κ B and c-jun N-terminal kinase.

• NCBI Gene ID:

  115650

• Swiss Prot:

  Q96RJ3

• Accession Number:

  AAK91826

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Chemokines & Cytokines

• Purification:

  BAFF Receptor Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  BAFF Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  BAFF Receptor antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  20 kDa

• Fragment:

  IgG

• Symbol:

  TNFRSF13C

• Positive Control 2:

  Cat. No. 1406 - Mouse Spleen Tissue Lysate

• Positive Control 3:

  Cat. No. 1466 - Rat Spleen Tissue Lysate

• Positive Control 4:

  Cat. No. 1315 - Human Tonsil Tissue Lysate

• Positive Control 5:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 13C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3

• Background Reference 02:

  Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56

• Background Reference 03:

  Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3

• Background Reference 04:

  Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κ B, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81

• Other Product Names:

  BAFF Receptor Antibody: BAFFR, CD268, CVID4, BAFF-R, BROMIX, prolixin, BAFFR, BR3, Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  15208475

• Physical Properties:

  Liquid