Eotaxin Antibody

• Background:

  Eotaxin Antibody: Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also utilized as virus coreceptors for fusion and infection of cells. The eotaxin receptor CCR3 is required for HIV-1 entry into target cells such as microglia and eotaxin inhibits the infection of HIV-1.

• NCBI Gene ID:

  6356

• Swiss Prot:

  P51671

• Accession Number:

  CAB07027

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Chemokines & Cytokines, Infectious Disease

• Purification:

  Eotaxin Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/ml

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (80%)

• Buffer:

  Eotaxin Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Eotaxin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  9 - 18 kDa

• Fragment:

  IgG

• Symbol:

  CCL11

• Positive Control 2:

  Cat. No. 17-010 - HEK293 Cell Slide

• NCBI Official Name:

  Chemokine (C-C motif) ligand 11

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kitaura M, Nakajima T, Imai T, et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem 1996;271:7725-30

• Background Reference 02:

  Ponath PD, Qin S, Ringler DJ, et al. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 1996;97:604-12

• Background Reference 03:

  He J, Chen Y, Farzan M, et al. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature. 1997;385 (6617) :645-9

• Background Reference 04:

  Choe H, Farzan M, Sun Y, et al. The β -chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 1996;85:1135-48 (WD0500)

• Other Product Names:

  Eotaxin Antibody: SCYA11, SCYA11, Eotaxin, C-C motif chemokine 11

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  2462478

• Physical Properties:

  Liquid