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Z-AEVD-FMK

CAT: 0804-HY-125305-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125305-01Size:1 mg
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Description
Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells[1][2].
CAS Number
1135688-47-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-aevd-fmk.html
Purity
95.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(OC)C[C@@H](C(CF)=O)NC([C@H](C(C)C)NC([C@H](CCC(OC)=O)NC([C@H](C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
Molecular Formula
C28H39FN4O10
Molecular Weight
610.63
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Park SJ, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279 (49) :51057-67.|[2]Ekchariyawat P, et al. Apoptosis induced by avian H5N1 virus in human monocyte-derived macrophages involves TRAIL-inducing caspase-10 activation. Innate Immun. 2012 Jun;18 (3) :390-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 10

Chemical Information

Z-Aevd-fmk
CAS Number1135688-47-9
PubChem CID25108694
IUPAC Namemethyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxo-4-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoate
Molecular FormulaC28H39FN4O10
Molecular Weight610.6
XLogP1.4
Topological Polar Surface Area195
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count20
Heavy Atom Count43
Formal Charge0
Complexity987
SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChI
InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)/t17-,19-,20-,24-/m0/s1
InChIKey
CHZRBQFKZDGMTP-CDSYHYPYSA-N
Chemical Structure
2D Structure
2D structure of Z-Aevd-fmk
CAS: 1135688-47-9
CID: 25108694
Formula: C28H39FN4O10
MW: 610.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight610.6
XLogP31.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count20
Exact Mass610.26502162
Monoisotopic Mass610.26502162
Topological Polar Surface Area195 Ų
Heavy Atom Count43
Formal Charge0
Complexity987
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1162-5Z-AEVD-FMK
AB-022Z-AEVD-FMK Recombinant Protein
FMK009Caspase-10 fmk Inhibitor Z-AEVD
1112-100Caspase-10 Inhibitor AEVD-FMK
MBS655418-01Caspase 10 Inhibitor, In Vivo, 10mM, Z-AEVD-FMK (FLICE2, Mch4)
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