LDL Receptor (LDLR) (NM_000527) Human Recombinant Protein

• Background:

  The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

• Synonyms:

  FH; FHC; FHCL1; LDLCQ2

• Gene ID:

  3949

• UniProt:

  P01130, A0A024R7D5

• Accession Number mRNA:

  NM_000527

• Chromosomal Location:

  19p13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis

• Field of Research:

  Endocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

• Molecular Weight:

  93 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LDLR

• Species:

  Human

• Protein ID:

  NP_000518

• Overview:

  Recombinant protein of human low density lipoprotein receptor (LDLR)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3949

• Uniprot URL:

  https://www.uniprot.org/uniprot/P01130

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000527

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000518