Neuraminidase (NEU1) (NM_000434) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein') . Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]

• Synonyms:

  NANH; NEU; SIAL1

• Gene ID:

  4758

• UniProt:

  Q99519, Q5JQI0

• Accession Number mRNA:

  NM_000434

• Chromosomal Location:

  6p21.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Lysosome, Other glycan degradation, Sphingolipid metabolism

• Field of Research:

  Lysosome, Other glycan degradation, Sphingolipid metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  29118338

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  40.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NEU1

• Species:

  Human

• Protein ID:

  NP_000425

• Overview:

  Recombinant protein of human sialidase 1 (lysosomal sialidase) (NEU1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4758

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99519

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000434

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000425