Thyroid Hormone Receptor alpha (THRA) (NM_003250) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Synonyms:

  AR7; c-ERBA-1; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2; TRalpha

• Gene ID:

  7067

• UniProt:

  P10827

• Accession Number mRNA:

  NM_003250

• Chromosomal Location:

  17q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Neuroactive ligand-receptor interaction

• Field of Research:

  Neuroactive ligand-receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

• Molecular Weight:

  54.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  THRA

• Species:

  Human

• Protein ID:

  NP_003241

• Overview:

  Recombinant protein of human thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) (THRA), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7067

• Uniprot URL:

  https://www.uniprot.org/uniprot/P10827

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003250

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003241