Thyroid Hormone Receptor beta (THRB) (NM_001128177) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH) . Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2; TRbeta

• Gene ID:

  7068

• UniProt:

  P10828, A0A024R2I8

• Accession Number mRNA:

  NM_001128177

• Chromosomal Location:

  3p24.2

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Neuroactive ligand-receptor interaction

• Field of Research:

  Neuroactive ligand-receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.

• Function:

  Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

• Molecular Weight:

  52.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  THRB

• Species:

  Human

• Protein ID:

  NP_001121649

• Overview:

  Purified recombinant protein of Human thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) (THRB), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7068

• Uniprot URL:

  https://www.uniprot.org/uniprot/P10828

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001128177

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001121649