DCUN1D5 (NM_032299) Human Recombinant Protein

• Background:

  Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26906416, PubMed:23201271, PubMed:19617556) . May play a role in DNA damage response and may participate to cell proliferation and anchorage-independent cell growth (PubMed:23098533, PubMed:24192928) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  SCCRO5

• Gene ID:

  84259

• UniProt:

  Q9BTE7, A0A024R3A2

• Accession Number mRNA:

  NM_032299

• Chromosomal Location:

  11q22.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  27.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DCUN1D5

• Species:

  Human

• Protein ID:

  NP_115675

• Overview:

  Recombinant protein of human DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) (DCUN1D5)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/84259

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BTE7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_032299

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_115675