RhoGDI (ARHGDIA) (NM_004309) Human Recombinant Protein

• Background:

  This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

• Synonyms:

  GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1

• Gene ID:

  396

• UniProt:

  P52565, V9HWE8

• Accession Number mRNA:

  NM_004309

• Chromosomal Location:

  17q25.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Neurotrophin signaling pathway

• Field of Research:

  Neurotrophin signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  23 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ARHGDIA

• Species:

  Human

• Protein ID:

  NP_004300

• Overview:

  Recombinant protein of human Rho GDP dissociation inhibitor (GDI) alpha (ARHGDIA)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/396

• Uniprot URL:

  https://www.uniprot.org/uniprot/P52565

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004309

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004300