JAB1 (COPS5) (NM_006837) Human Recombinant Protein

• Background:

  The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

• Synonyms:

  CSN5; JAB1; MOV-34; SGN5

• Gene ID:

  10987

• UniProt:

  Q92905, A0A024R7W9

• Accession Number mRNA:

  NM_006837

• Chromosomal Location:

  8q13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protease, Transcription Factors

• Molecular Weight:

  37.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  COPS5

• Species:

  Human

• Protein ID:

  NP_006828

• Overview:

  Recombinant protein of human COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (COPS5)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10987

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q92905

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006837

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006828