JAB1 (COPS5) Mouse Monoclonal Antibody [Clone ID: LBI2B12]

• Background:

  The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq]

• Synonyms:

  CSN5; JAB1; MOV-34; SGN5

• Gene Name:

  COP9 signalosome subunit 5

• Gene ID:

  10987

• UniProt:

  Q92905

• Conjugation:

  Unconjugated

• Concentration:

  0.76 mg/ml

• Dilution:

  WB 1:2000, IHC 1:150, IF 1:100

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, Protease, Transcription Factors

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  COPS5

• Overview:

  COPS5 (JAB1) mouse monoclonal antibody, clone LBI2B12

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10987

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q92905