Flavin containing monooxygenase 4 (FMO4) (NM_002022) Human Recombinant Protein

• Background:

  Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria) . Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

• Synonyms:

  FMO2

• Gene ID:

  2329

• UniProt:

  P31512

• Accession Number mRNA:

  NM_002022

• Chromosomal Location:

  1q24.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Drug metabolism - cytochrome P450

• Field of Research:

  Drug metabolism - cytochrome P450

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  63.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  FMO4

• Species:

  Human

• Protein ID:

  NP_002013

• Overview:

  Recombinant protein of human flavin containing monooxygenase 4 (FMO4)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/2329

• Uniprot URL:

  https://www.uniprot.org/uniprot/P31512

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002022

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002013