SIGIRR (NM_021805) Human Recombinant Protein

• Background:

  Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  IL-1R8; TIR8

• Gene ID:

  59307

• UniProt:

  Q6IA17

• Accession Number mRNA:

  NM_021805

• Chromosomal Location:

  11p15.5

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors, Transmembrane

• Molecular Weight:

  45.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SIGIRR

• Species:

  Human

• Protein ID:

  NP_068577

• Overview:

  Purified recombinant protein of Homo sapiens single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/59307

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6IA17

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021805

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_068577