Sigirr (NM_023059) Mouse Recombinant Protein

• Background:

  Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI256711; TIR8

• Gene ID:

  24058

• UniProt:

  Q9JLZ8, Q3UKS3

• Accession Number mRNA:

  NM_023059

• Chromosomal Location:

  7 F5

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  46.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Sigirr

• Species:

  Mouse

• Protein ID:

  NP_075546

• Overview:

  Purified recombinant protein of Mouse single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/24058

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9JLZ8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_023059

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_075546