CIRBP (NM_001280) Human Recombinant Protein

• Background:

  Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity) . Promotes assembly of stress granules (SGs), when overexpressed.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  CIRP

• Gene ID:

  1153

• UniProt:

  Q14011, Q53XX5

• Accession Number mRNA:

  NM_001280

• Chromosomal Location:

  19p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  18.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CIRBP

• Species:

  Human

• Protein ID:

  NP_001271

• Overview:

  Recombinant protein of human cold inducible RNA binding protein (CIRBP), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1153

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q14011

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001280

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001271