ERAB (HSD17B10) (NM_004493) Human Recombinant Protein

• Background:

  This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

• Synonyms:

  17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; HSD10MD; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1

• Gene ID:

  3028

• UniProt:

  Q99714, A0A0S2Z410

• Accession Number mRNA:

  NM_004493

• Chromosomal Location:

  Xp11.22

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation

• Field of Research:

  Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  25.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HSD17B10

• Species:

  Human

• Protein ID:

  NP_004484

• Overview:

  Recombinant protein of human hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10), nuclear gene encoding mitochondrial protein, transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3028

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q99714

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004493

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004484