RAB35 (NM_006861) Human Recombinant Protein

• Background:

  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  H-ray; RAB1C; RAY

• Gene ID:

  11021

• UniProt:

  Q15286

• Accession Number mRNA:

  NM_006861

• Chromosomal Location:

  12q24.23

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  22.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RAB35

• Species:

  Human

• Protein ID:

  NP_006852

• Overview:

  Recombinant protein of human RAB35, member RAS oncogene family (RAB35)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/11021

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15286

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006861

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006852